Our blogs and videos choice: human mitochondrial dna

Adam & Eve and the Empathic Civilization

A couple points boggle the mind. Gets a little deep so you are forewarned. Jeremy Rifkin mentions how we did all come from Adam and Eve but it's not what we think. I had to look this up too but the Mitochondrial "Eve" and Y-Chromosomal "Adam" that Jeremy Rifkin talks about did not actually live in the same time period nor did they mate. Mitochondrial "Eve" lived 50,000 years before Y-Chomosomal "Adam" but the theory is that every human today can trace their mitochondrial DNA through their mothers to this one female, and all males can trace their paternal lineage to this one male. Crazy [more...]

Date: 2010-09-26 23:50:00

Blog posts (42) | Videos (20)

Human remains identified as those of Alice Donovan | SCNOW

The remains werefirst sent to a lab at the University of South Carolina for possible mitochondrial DNA extraction and testing. But forensic scientists at the state crime lab weren’t able to pull enough DNA from the skeletal remains for a positive identification. The Horry County Police Department since had been in contact with the Health Science Center at the University of North Texas, where the remains — along with DNA swabs taken during the Jan. 27 search from Gilchrist and Warner — were sent for additional testing, Horry County Police Sgt. Robert Kegler said. Most of the search for [more...]

Date: 2009-07-24 21:51:37

ISPUB - What's There In Our Genes? A Case For A More Inclusive And ...

We need better reviews, use of both qualitative and quantitative data as well as much more rigorous testing of newer and older models. Only then may we make full use of this large amount of data that has already been collected over the years. What we have described here, for now, presents part of the picture seen from the Indian subcontinent as an example. However, this situation is probably true of other parts of the world as well, perhaps even those areas where it has been assumed that the data is likely to be homogenous. Thus, even biological anthropologists need to add new sensitivities [more...]

Date: 2010-10-07 04:39:48

The Real Eve Streaming

The Real Eve Streaming. Movie Title: The Real Eve Average customer review: The Real Eve is available for streaming or downloading. Click Here to Stream or Download The Real Eve I highly recommend this work!!! Two-thumbs up. It’s possibly the best allotment of work on the genealogy and evolution of humans I have seen in my lifetime. By researching and explaining the migration of novel humans from Africa throughout the rest of the world the research completely challenges our whole conception of Speed since it proves that we are all related somehow — every single person on the planet can [more...]

Date: 2010-10-05 14:40:23

Human Ancestry And Migration

The Genographic Project, launched in April 2005, is a five-year genetic anthropology study that aims to map historical human migration patterns by collecting and analyzing DNA samples from hundreds of thousands of people from around the world. Field researchers at 10 regional centers around the world collect DNA samples from indigenous populations. The company also sells self-testing kits: for US$100 anyone in the world can order a self-testing kit from which a mouth scraping (buccal swab) is obtained, analyzed and the DNA information placed on an Internet accessible database. The genetic [more...]

Date: 2010-08-04 01:49:04

Forensic DNA Analysis – What is Mitochondrial DNA?

Mitochondrial DNA can also be found in some tissues where nuclear DNA normally does not exist. For instance, dead cellular debris can be found in human hair. However, the only thing that is living in human hair the follicle, [more...]

Date: 2010-08-22 08:31:49

race/history/evolution notes: Highly divergent ancient hominin ...

Svante Paabo assumes "some new creature" "carried this mitochondrial genome out of Africa about a million years", as do most commentators. It strikes me that a multiregionalist explanation is as consistent if not more consistent with the evidence at hand. If we entertain the possibility that "African Eve" ultimately descends from Eurasian Homo erectus, we don't need to posit some unknown intermediate "out of Africa" event. Reference: Johannes Krause, Qiaomei Fu, Jeffrey M. Good, Bence Viola, Michael V. Shunkov, Anatoli P. Derevianko & Svante Pääbo. The complete mitochondrial DNA genome of [more...]

Date: 2010-03-25 03:22:00

A Girl In Mexico In The 1930s Went Into A Mineshaft And Found An ...

However, Mr Pye believed the samples were contaminated and had it re-tested by a different lab in 2004, which managed to recover mitochondrial DNA, but not nuclear DNA. This meant either the nuclear DNA was too degraded to recover, or the DNA from the father was too different from that of a human to be detected. This year, the skull was tested by an ultra high-tech genetic lab, which was unable to match part of the nuclear DNA samples to any other samples in the enormous genetic database at the US National Institutes of Health. Mr Pye is convinced it is only a matter of time before the [more...]

Date: 2010-10-04 18:17:19

Mitochondrial Eve screws Adam

The Mitochondrial Eve thing refers to the most recent common ancestor for all extant humans and is possible because mitochondrial DNA is inherited unmixed from the female parent. It's good science and currently points to the most resent common female ancestor living about 200 000 years ago somewhere in Africa and can be used as a predictor for the various migration hypotheses, for instance it casts doubt on the popular "out of Africa" hypothesis. Now the bible says people originated when god created Adam and Eve, and they were therefore the first two people. After the debacle with the fruit [more...]

Date: 2010-08-02 05:57:14

Black Womyn on Coming Out [VIDEO]

"Woman" and "human" were once the same word. Sound it out: hoo-man. Woo-man. This should come as no surprise to those who are aware that the first true humans were female, not male. "Genetic Eve" and her daughters were the founders of humanity. Eve's sons, if she had any, no doubt had about the same level of humanity, but couldn't pass it on because they didn't share their mitochondrial DNA with their offspring. Humanity was spread through the maternal line for [more...]

Date: 2010-10-12 17:55:56

Origin of the human malaria parasite in gorillas - TalkRational

But researchers from the US, three African countries, and Europe have examined malaria parasites in great ape faeces. They found the DNA from western gorilla parasites was the most similar to human parasites. Liu, W. et al. (2010) Origin of the human malaria parasite Plasmodium falciparum in gorillas. Nature, 467, 420-425. Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting humans, yet the origin and evolutionary history of this important pathogen remain controversial. Here we develop a single-genome amplification strategy to identify and characterize [more...]

Date: 2010-09-22 17:35:43

Case Analyst (Salt Lake City)

Successful candidate will perform genotyping analysis. Experience using GeneMapper genotyping software a plus. Experience performing DNA extraction, PCR and genotyping for STR analysis and mitochondrial sequencing essential. Other lab duties as directed. Required: • BS in Biochemistry, Molecular Biology, Biology or related field • 1 year experience in laboratory • Knowledge of molecular biology testing, analysis and reporting. • Must be able to use hands, stand for periods of time and lift up to 20 lbs. Preferred: • Computer and Microsoft applications proficiency • 2 years [more...]

Date: 2010-10-01 04:43:12

PLoS ONE: Evidence of Authentic DNA from Danish Viking Age ...

Linea Melchior1, Toomas Kivisild2, Niels Lynnerup3, Jørgen Dissing1*1 Research Laboratory, Institute of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark, 2 Leverhulme Center for Human Evolutionary Studies, The Henry Wellcome Building, University of Cambridge, Cambridge, United Kingdom, 3 Laboratory of Biological Anthropology, Institute of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark Abstract Top Background Given the relative abundance of modern human DNA and the inherent impossibility for incontestable proof of authenticity, results obtained on ancient [more...]

Date: 2008-05-28 07:00:00

Cancer type-specific modulation of mitochondrial haplogroups in ...

Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer (BMC Cancer) Background: Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic diseases and cancer. Methods: To investigate whether mtDNA haplogroups contribute to the occurrence of cancer in a specific Chinese population, we have carried out a comprehensive case-control study of mtDNA from large cohorts of patients with three common cancer [more...]

Date: 2010-08-12 17:59:10

Raciality.com - and Brutality: Haplogroup H is the most common ...

In human mitochondrial genetics, Haplogroup H is a human mitochondrial DNA (mtDNA) haplogroup. Haplogroup H is a descendant of haplogroup HV. The Cambridge Reference Sequence (CRS), the human mitochondrial sequence to which all other sequences are compared, belongs to haplogroup H. Haplogroup H is the most common mtDNA haplogroup in Europe. About one half of Europeans are of mtDNA haplogroup H. The haplogroup is also common in North Africa and the Middle East. The majority of the European populations have an overall haplogroup H frequency of 40%–50%. Frequencies decrease in the southeast of [more...]

Date: 2009-04-13 15:58:00

Examining Mitochondrial DNA Damage

Under normal growth conditions, ROS leads to a low level of mtDNA and nuclear DNA (nDNA) damage, which is rapidly repaired, and most oxidative DNA lesions are repaired by the base excision repair (BER) pathway ... The purpose of the study presented here was to determine if there is an increased mtDNA in the lens with age. ... The gene expression key BER enzymes decreased with age, which caused a decrease in the repairing capability of the mtDNA and the accumulation of mtDNA damage. The increased mtDNA damage and decreased expression of BER enzymes may cause a "vicious cycle" of [more...]

Date: 2010-09-09 03:15:50

What is the mitochondrial disease known as LHON?

LHON is usually due to one of three pathogenic mitochondrial DNA (mtDNA) point mutations. These mutations are at nucleotide positions 11778 G to A, 3460 G to A and 14484 T to C, respectively in the ND4, ND1 and ND6 subunit genes of complex I of the oxidative phosphorylation chain in mitochondria. Men cannot pass on the disease to their offspring. Clinically, there is an acute onset of visual loss, first in one eye, and then a few weeks to months later in the other. Onset is usually young adulthood, but age range at onset from 8-60 is reported. This typically evolves to very severe optic [more...]

Date: 2010-09-15 15:40:13

How to Maximize Free DNA Testing

DNA testing has not been limited to the study of the human gene, but has also included that of our beloved canines. DNA testing centers for dogs are open to identify the breeds and ancestry of our pets. Free DNA testing also shoots from legal cases with proceedings done underway. DNA testing for these circumstances can include not only the victim and possible suspects but also other individuals present at the crime scene. Some legal reasons that require DNA testing are for alimony or patrimony reasons. In these cases, the genetic markers are looked into to determine, for example, the [more...]

Date: 2010-05-03 22:41:52

Philippine Mitochondrial DNA Diversity answers some questions on ...

Tabbada and her co-authors writing in Molecular Biology and Evolution, may have uncovered some clues supporting the Bellwood’s theory as they describe mitochondrial DNA (mtDNA) differences from Philippine samples and investigate these variations with respect to the genetic diversity of other Southeast Asian populations . Here are some of their results (most are written in the authors’ words, hence the quotes). 94% of Philippine samples are part of the mtDNA haplogroups previously identified in East Asian and Southeast Asian populations - subclades of haplogroups B4, B5, D, E, F, [more...]

Date: 2010-09-20 10:35:59

geek speak - Bio-Synthesis, Inc. Begins Mitochondrial DNA Testing

Bio-Synthesis, Inc. begins Mitochondrial DNA Testing or MtDNA, making it one of only a handful of labs to perfect the technology. MtDNA Testing allows Forensic scientist to get a profile from samples that are old or possibly damaged, where the usual technique may not be effective. (Media-Newswire.com) - Recently Bio-Synthesis, Inc. has begun Mitochondrial or MtDNA Testing making it one of only 4 labs in the United States who have perfected the technology and offer it commercially. This expansion has allowed for more varied test options and opens the door to new industries that may benefit [more...]

Date: 2008-12-03 09:43:00

Age Confirmed for 'Eve,' Mother of All Humans: 200000 years

“There is always some other female that predated mitochondrial Eve, whose DNA didn’t make it up to modernity,” said Marek Kimmel, a professor of statistics at Rice University. “So the age of the mitochondrial Eve is always less than the age of the true, first female modern human.” Full Article at [more...]

Date: 2010-08-21 07:34:22

The Journey of Man: A Genetic Odyssey

A very nice book if one is interested in understanding how DNA analysis is being used to trace human migration and from where it started. Would like more substance. There is no in-depth explanation of mitochondrial DNA dating, Y-chromosome dating, etc. More red meat than Seven Daughters of Eve for sure! Does this book have. Interesting. I thought it was a good book- and being a molecular biologist who is familiar with the worlds advanced knowledge of genetics, I am quite comfortable with my African origins and the obvious fact that we (meaning all races) are all extremely similar. Fascinating [more...]

Date: 2010-05-23 10:41:42

dna sequencing

DNA sequencing reactions all use a primer to initiate DNA synthesis.  A Quicktime animation of how dideoxy nucleotides are incorporated into DNA in sequencing reactions. Nucleic acid sequence This sequence is written as a succession of letters representing a real or hypothetical DNA molecule or Sequences can be read from the biological raw material through DNA . DNA Sequencing – Real Time DNA analysis Information With the latest chellenges in DNA Sequencing, our organization looks to unravel the myths, truths and most essential assets in the deconstruction of genes. DNA Sequencing The [more...]

Date: 2010-07-09 03:20:29

The Evolution of Human Populations in Arabia: Paleoenvironments ...

Section two of this volume places its focus on “genetics and migration” with three chapters. The first two, “Mitochondrial DNA Structure of the Yemeni Population: Regional Differences and the Implications for Different Migratory [more...]

Date: 2010-07-09 13:43:25

HowStuffWorks "Are we all descended from a common female ancestor?"

The researchers examined the mitochondrial DNA (mtDNA) taken from 147 people across all of today's major racial groups. These researchers found that the lineage of all people alive today falls on one of two branches in humanity's family [more...]

Date: 2008-01-14 08:00:00

Australian Aborigines Were Once Indians - Study

Dr Raghavendra Rao worked with a team of researchers from the Anthropological Survey of India to sequence 966 complete mitochondrial DNA genomes from Indian 'relic populations'. He said, "Mitochondrial DNA is inherited only from the mother and so allows us to accurately trace ancestry. We found certain mutations in the DNA sequences of the Indian tribes we sampled that are specific to Australian Aborigines. This shared ancestry suggests that the Aborigine population migrated to Australia via the so-called 'Southern Route'." The 'Southern Route' dispersal of modern humans suggests movement of [more...]

Date: 2010-10-08 03:08:00

Dienekes' Anthropology Blog: Complete Neanderthal mtDNA sequence

A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA generated from ∼0.3 g of bone. Analysis of the assembled sequence unequivocally establishes that the Neandertal mtDNA falls outside the variation of extant human mtDNAs, and allows an estimate of the divergence date between the two mtDNA lineages of 660,000 ± 140,000 years. Of the 13 proteins encoded in the mtDNA, subunit 2 of cytochrome c oxidase of the mitochondrial electron transport chain has experienced the largest number [more...]

Date: 2008-08-07 16:44:00

Chemical synthesis of the mouse mitochondrial genome « too New to yoU

However, this study used the basic synthesis unit is a nucleotide containing thousands of DNA (deoxyribonucleic acid) fragments. Because the basic synthesis unit larger, the final synthesis in the verification is correct the genome will bring some trouble. Thus, the research team invented a new method of synthesis of the genome, using the basic synthesis unit is only 60 nucleotides of DNA containing fragments, placing them well-designed environment, you can connect into the whole genome. The group believes that this is by far the easiest way to synthetic genome. In order to verify the [more...]

Date: 2010-10-13 07:19:52

DNA method gives new perspective on the Mysteries of Nature

We demonstrate that this new approach enables the assignment of virtually all the generated DNA sequences to the correct source once sequencing anomalies are accounted for (miss-assignment rate less than 0.4%). Therefore, the method enables accurate sequencing and assignment of homologous DNA sequences from multiple sources in single high-throughput GS20 run. We observe a bias in the distribution of the differently tagged primers that is dependent on the 5' nucleotide of the tag. In particular, primers 5' labelled with a cytosine are heavily overrepresented among the final sequences, while [more...]

Date: 2007-02-15 17:01:00

Dienekes' Anthropology Blog: mtDNA of Yemeni and Ethiopian Jews

The way I see it, only a large-scale study of all global Jewish populations may uncover verified ancient Jewish lineages for both Y-chromosomes and mtDNA. The recent studies on Jews have uncovered several genetic sub-clusters of Jews, and only lineages that occur in 2 or more of these clusters, and preferably geographically separated ones have a strong claim of representing original Jewish lineages. There is a limit on what can be uncovered about the past from the study of living populations. American Journal of Physical Anthropology doi: 10.1002/ajpa.21360 Mitochondrial DNA reveals distinct [more...]

Date: 2010-07-14 18:00:00

AJHG - Previous Estimates of Mitochondrial DNA Mutation Level ...

The Distribution of Mitochondrial DNA Heteroplasmy Due to Random Genetic Drift The American Journal of Human Genetics, Volume 83, Issue 5, 17 November 2008, Pages 582-593 Passorn Wonnapinij, Patrick F. Chinnery and David C. Samuels Abstract Cells containing pathogenic mutations in mitochondrial DNA (mtDNA) generally also contain the wild-type mtDNA, a condition called heteroplasmy. The amount of mutant mtDNA in a cell, called the heteroplasmy level, is an important factor in determining the amount of mitochondrial dysfunction and therefore the disease severity. mtDNA is inherited maternally, [more...]

Date: 2010-04-01 07:00:00

Can DNA Tests Reveal Nationality? » Scienceline

The Borders Agency is primarily using two types of DNA tests: mitochondrial DNA tests, which examine the genetic information stored in a cellular structure called a mitochondrion, and what are called Y-line tests, which look at markers on the Y-chromosome passed from father to son. These tests have been widely used to examine people’s ancestral heritage. Since certain genetic variations are typical in certain areas, geneticists can use an individual’s DNA to estimate where their ancestors came from. But when this technique is used to look at someone’s nationality rather than the origin [more...]

Date: 2009-12-30 06:05:09

Cat DNA Can Aid in Criminal Investigations | easyDNA Blog

If you have ever inquired about a hair DNA test or know some of the basics of DNA you may know that DNA is found throughout nucleated cells in the body. Since hairs are simply made up of protein then we know that there is no nuclear DNA in hair. The same applies for cats- there is no nuclear DNA in cat hair. However, cat hair and human hair contain what is known as MtDNA (mitochondrial DNA) and this, like nuclear DNA, is unique to each of us. Cat DNA convicts murderer A body was found in a grave on Prince Edward Island, Canada. Police investigators identified the body as belonging to Shirley [more...]

Date: 2010-05-20 08:24:39

DNA Testing | We are all African | Mahala

If you could email your ancestors, what would you want to know? Family legend or delusions of grandeur may suggest you are royalty: A Nubian Princess, the fruit of Genghis Khan’s loins, or a descendant of Shaka Zulu’s warrior clan. You may be some, or all of those things, but most likely, you’re a mongrel. Up until last week I thought I was pretty vanilla. An average 5th generation white settler, much like, in terms of my genetic cocktail, any other rooinek. But then I did a DNA test. Not because I wanted to find out the obvious stuff, like where my Grandparents were born, but to [more...]

Date: 2010-06-18 07:00:15

Mother of All Humans Lived 6000 Years Ago

Further, for so few--only 21.6 nucleotides out of 16,569--DNA differences to have accumulated at anything near the measured mutation rates, a much shorter time than "200,000 years" must have transpired since Mitochondrial Eve arrived on the scene. To stretch out across evolutionary time the occurrences of so few DNA changes requires a gymnastic juggling of the coefficients used in the various models, and appears to require a biologically unrealistic, super-slow mutation rate. Making the data fit vast timescales requires the use of a broken, circular-reasoning-based, evolutionary [more...]

Date: 2010-09-07 08:00:00

Sandwalk: Nobel Laureate: Walter Gilbert

The Nobel Prize in Chemistry 1980. "for their contributions concerning the determination of base sequences in nucleic acids" Walter Gilbert (1932 - ) was awarded the Nobel Prize for developing a chemical method of sequencing DNA (with Allan Maxam). The method relied on chemical reactions that cleaved DNA at specific residues. By carrying out partial reactions where only one cleavage occurred in each DNA strand, it was possible to separate the cleavage products on an acrylamide gel and determine the position of each residue by the length of the fragment. The chemical sequencing strategy has [more...]

Date: 2008-12-10 14:35:00

Dienekes' Anthropology Blog: Origin of mtDNA haplogroup H

More than a third of the European pool of human mitochondrial DNA (mtDNA) is fragmented into a number of subclades of haplogroup (hg) H, the most frequent hg throughout western Eurasia. While there has been considerable recent progress in studying mitochondrial genome variation in Europe at the complete sequence resolution, little data of comparable resolution is so far available for regions like the Caucasus and the Near and Middle East - areas where most of European genetic lineages, including hg H, have likely emerged. This gap in our knowledge causes a serious hindrance for progress in [more...]

Date: 2006-11-10 19:17:00

The Tea Party supports puppy mills? Really?

Interesting animal news and pet news. Pet related information, animal related web sites, stories about pets and wild animals. Humor and photos of animals. Bizarre pet products, merchandise and pet supplies. Terrierman‘s lead paragraph says it all, so he’ll kick off the topic for us: Apparently Joe the Plumber and the Tea Party support Puppy Mills. No, I am not making this up. Here’s the link you want, but you will also note that there is no link to the actual legislation in question. What’s going on? It seems the Tea Party and “Joe the Plumber”  have determined that a ballot [more...]

Date: 2010-10-07 13:10:07

Links of London almost entirely

Links of London sale Six years ago the term "genetic genealogy" was meaningless, says Bennett Greenspan, head of Family Tree DNA, a testing firm with 52,000 customers. "Now the interest is huge." As individuals track down their personal family narratives, population geneticists are seeking to tell the larger story of humankind. Our Links of London Black Friendship Bracelet recent common ancestorsa genetic "Adam" and "Eve"have been traced back to Africa, and other intriguing forebears are being discovered all over the map. One group of scientists recently found that 40 percent of the world’s [more...]

Date: 2010-10-07 02:55:30

KABT BioBlog | Blog | The BEN portal of the National Science ...

Mitochondrial DNA Clarifies Human Evolution : This article and associated material/lesson plan can be used to identify the structure and function of mitochondria and to understand mitochondria’s role in evolution. A Beginner’s Guide to the Study of Plant Structure : A variation of this resource can provide guidelines for conducting a laboratory exercise in botany and plant structure. Students will become familiar with the standard techniques of light microscopy, including staining, sectioning, and drawing. Resources for AP Biology Teachers: Renewable Energy Curriculum Units : The [more...]

Date: 2010-10-04 14:56:44

Whiskey Tango Foxtrot Oscar: Swearing at an oath

With this definition in mind, the evil that Israel has done becomes manifest. The legislation reeks of injustice. It only applies to one subset of Israel, to the Arab minority.  It is clearly targeted toward them. It is making a blanket claim that all Israeli Arabs are forthwith considered fifth columnists. By legislative fiat Israel has now declared that Arab subversion of the Jewish state is now passed down genetically, just like Mitochondrial DNA. All Arabs are guilty of treason without exception and must prove by solemn oath otherwise. The law ironically is disobedient to the rules of [more...]

Date: 2010-10-13 12:27:00

Arab News Blog » Israel Declares for Ethnic Nationalism

In a globalizing world with massive labor migration, ethnic nationalism is a recipe for race war. And, of course, as a historian I reject the whole idea of a “race” in the 19th century Romantic nationalist sense as a figment of the imagination. Brian Sykes found on looking at the mitochondrial DNA of Europeans that all the women had only one of 7 haplotypes or patterns in the chromosomes, and that the same 7 appeared in all linguistic and national groups, including e.g. the Basque, though the proportions varied. Germans are no different in this regard from the Irish or from Bulgarians. [more...]

Date: 2010-10-11 16:20:22

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