Our blogs and videos choice: dna sequencer

PubMed: Identification of methylated regions with peak search ...

Massively parallel methylated DNA immunoprecipitation sequencing combined with methylation DNA immunoprecipitation was adopted to obtain methylated DNA sequence data from human leukemia cell line K562, and the methylated regions were identified by peak search based on Poison model. From our result, 140 958 non-overlapping methylated regions have been identified in the whole genome. Also, the credibility of result has been proved by its strong correlation with bisulfite-sequencing data (Pearson R(2)=0.92). It suggests that this method provides a reliable and high-throughput strategy for whole [more...]

Date: 2010-10-07 10:10:13

Blog posts (459) | Videos (52)

Interview with Arun Kumar: Genographic Postdoc, India - Genographica

I have worked with state of the art DNA technologies like Taqman assays, Fragment Analysis and DNA sequencing and have gained a true global experience working with on the Genographic team. Everyday brings a new learning experience! GP: Wait a minute, for those of us that aren't scientists, what is an assay? Arun Kumar: An assay is a way to genotype a specific mutation within DNA. In other words, it is an experiment that helps to identify a specific nucleotide with Y chromosome or mitochondrial DNA. This mutation will define the ancestral or derived state which will help to identify the [more...]

Date: 2010-10-07 19:07:51

Welcome to Sage

Synthetic genomics is the chemical synthesis of DNA sequences. The synthesized sequences can already exist – as in the chemical synthesis of genes naturally found in an organism – or it can involve the synthesis of novel, unnatural DNA sequences. Synthetic biology is both the design and construction of new biological parts, devices, and systems and the redesign of existing natural biological systems for useful purposes. Because the synthetic life sciences may enable the synthesis of biomolecules, whole genomes, and even simple life forms, these sciences have enormous potential, as they [more...]

Date: 2010-09-16 13:18:45

DNA sequencing » Blog Archive » DNA Analysis

DNA profiling (also called DNA testing, DNA typing, or genetic fingerprinting) is a DNA profiling involved restriction enzyme digestion, followed by Southern blot analysis. DNA fingerprint: Definition from Answers.com DNA fingerprint n. An individual’s unique sequence of DNA base pairs, determined by exposing a sample of the person’s DNA to molecular [more...]

Date: 2010-08-31 16:03:47

Research Assistant 2 - OHSU Human Resources

Key responsibilities include: DNA sequencing; maintaining a colony of experimental mice and is responsible for genotyping, pre- and post-surgical care and monitoring, and minor surgical procedures on the animals; assist in the daily operation of the lab; Collects, records, organizes and verifies the accuracy of data. Conducts literature searches and summarizes information in an appropriate format for a particular study; documents and interprets results of experiments and reports to principal investigator; presents experimental results at lab meetings and participates in journal and research [more...]

Date: 2010-10-12 08:00:00

Al Fin: A Hint of Epigenetics

We are learning that the genetic code is only the short, first chapter in a very long book. The non-genetic "code" -- the non-coding DNA and RNA -- has a logic all its own. We are just beginning to decrypt the obscure cipher. The possibilities for the transformation of life as we know it seem just as grandiose as were the hopes of the early promoters of the human genome enterprise. Only this time, we are working at a deeper level of sophistication. How many more levels will we need to descend before we reach the promised land of genetic medicine? ... some 95 or 98 percent of human DNA was [more...]

Date: 2010-10-13 15:07:00

Mitochondrial Disease can be diagnosed with a new test.

The SOLiD NextGen sequencing platform developed by Life Technologies was used for testing because of its low error rate and high throughput. This rigorous sequencing of mitochondrial DNA by MitoDx can detect mixtures (heteroplasmy) of normal and mutant DNA even when the mutant or normal form is present at very low levels. This allows mitochondrial disease to be evaluated much more sensitively in an accessible tissue like blood or saliva. Richard Boles, MD, the Director of the Mitochondrial and Metabolic Disorders Clinic at Childrens Hospital Los Angeles says, “MitoDx has confirmed the [more...]

Date: 2010-09-29 04:56:00

Is It Safe To Have Personal DNA Testing? – Science

This may possibly probably weighing straight down criticisms against exclusive DNA testing. In addition, price of screening will be lowered being a end result of competitors that allow it to be more affordable and less expensive software applications prices for public. It higher that individuals succumb for the solitude problems as screening requirements mass submission of DNA examples in to the database. Certainly, problems these kinds of as mass submission of examples could slow straight down the means of investigation of misdemeanors. As all personnel would make faults – we understand in [more...]

Date: 2010-10-04 02:18:56

Forensic Serology Information Page

What is Forensic Serology?According to forensic serologist Marcella Jones of www.ForensicMentor.com, forensic serology is the analysis of body fluids as they relate to forensic cases, including DNA analysis. Accordingly, the role of the forensic serologist involves:Examining evidence for the presence of body fluids e.g. blood, semen, hair, tissue, saliva, feces, and urineEvaluating evidence for potential DNA analysisEvaluating species of body fluidsPerform PCR (polymerase chain reaction) based typing of STR (short tandem repeat sequences) of genomic DNA, or mitochondrial sequence analysis of [more...]

Date: 2010-02-04 08:00:00

My Helical Tryst: Single Molecule DNA Sequencing

There are a number of companies that have recently launched competing technology platforms that are capable of sequencing DNA at the single molecule level. You may ask, why? Well, the answer is simply cost-effectiveness. DNA sequencing technology has been around for several decades, and to date, the Human Genome Project (HGP) is considered the pinnacle application of that technology. The cost of the HGP was approximately $3 billion and took about a decade and half. It was the molecular biology equivalent of putting a man on the moon. But what is the next step? Well, if we can systematically [more...]

Date: 2009-02-11 22:17:00

Learn The Basic Process Of DNA Paternity Testing

Technology has finished so many for many of us – in actuality it has helped us strike many of the shortcomings in life. It certainly has done things the lot easier as well as many faster to accomplish. Technology, indeed, has facilitated lots of discoveries creation hold up reduction of the consternation as well as has aided information exchnage even to distant flung tools of the world.The area of healing scholarship is the single of the areas which has severely benefited from technological development.   One of the many appropriate contributions of scholarship in the healing margin is [more...]

Date: 2010-10-09 04:16:22

Preserving The Dna Of Endangered Species With The Natural History ...

Hi all, I wanted to tell you about some of the interesting new work I’ve been doing with the Natural History Museum in London. This new project is really an extension of the studies I’ve been doing in DNA sequencing. My team at Global Research, along with GE Healthcare and the Museum, are now trying to improve methods of obtaining DNA from fresh and preserved historical samples of endangered species (like the giant squid you see below) in order to learn more about them. In the past the team has worked on methods to enzymatically amplify specimen DNA, long term preservation of samples, and [more...]

Date: 2010-08-30 13:56:36

Healing Dna With Light, Sound And Acupuncture

There are many other ways to enhance the torsion field in our body like sunlight, negatively charged fresh air, clean water, natural medicines, and healthy foods.   Another way to improve and repair DNA on a cellular level is acupuncture. Acupuncture can be used on the pericardium and heart meridians to activate the thymus gland and improve immune function. This can be very useful in treating autoimmune diseases. Increased the energy in these meridians can activate higher frequencies. Higher frequencies lead to lower cellular oxidation rates and less cellular aging. Acupuncture on the Du [more...]

Date: 2010-09-07 12:05:19

Ph.D or post-doc assistantship in plant evolution/biogeography at ...

The successful applicant will choose one or more of these plant families to: generate flow cytometry data aimed at determining ploidy levels; generate nuclear DNA sequences and infer species trees; incorporate ecological data to investigate issues of niche conservatism vs. niche evolution in the selected groups. Requirements: Demonstrated experience in molecular, phylogenetic and flow-cytometry methods and/or ecological niche modeling will be highly valued in the selection process. Excellent knowledge of the English language, written and oral, required. Familiarity with additional European [more...]

Date: 2010-06-04 13:05:00

Basics: Sequencing DNA, Part 1 « Genetic Inference

However, in certain respects Sanger Sequencing is still top-of-the-range. The 4-channel capillary approach lets you sequence DNA pretty fast, and each machine can often do hundreds of reactions at once. It was these machines that first sequenced the human genome. In addition, you can sequence relatively long sequences of DNA; up to 1000 nucleotides (after that, it gets difficult to tell the difference between molecules of different sizes). We have yet to make a machine that can sequence DNA fragments of this length faster than Sanger Sequencing (yet…). The modern Sanger Sequencing machines [more...]

Date: 2009-04-17 21:31:39

Evolution News & Views: "Junk" DNA: Darwinism's Last Stand?

In 1980, Francis Crick and Leslie Orgel argued in Nature that "much DNA in higher organisms is little better than junk." The spread of junk DNA in the course of evolution "can be compared to the spread of a not-too-harmful parasite within its host." Since it is unlikely that such DNA has a function, "it would be folly in such cases to hunt obsessively for one." In a companion article, W. Ford Doolittle and Carmen Sapienza similarly argued that many organisms contain "DNAs whose only 'function' is survival within genomes," and that "the search for other explanations may prove, if not [more...]

Date: 2009-06-04 16:00:00

HHMI News: Timothy Harris to Deliver Public Talk at Janelia Farm

The event is free and open to the public, but tickets are required for admission. Directions for obtaining the tickets are available on the HHMI web site at www.hhmi.org/janelia/events.html. Seating is limited to 250 people. The lecture is the seventh in a series called “Dialogues of Discovery at Janelia Farm.” Past speakers in the series have included Thomas R. Cech, former president of HHMI and an HHMI investigator at the University of Colorado, Boulder; Roian Egnor, a fellow at the Janelia Farm Research Campus; Ronald M. Evans, an HHMI investigator at the Salk Institute for Biological [more...]

Date: 2010-10-04 17:01:00

C'mon, Forbes Wasn't Entirely Wrong About Monsanto - Matthew ...

Even the StarLink fiasco a decade ago, when an Aventis CropScience gene only approved for animal use got into Taco Bell taco shells that were sold in stores didn’t result in harm to people. There was some worry about butterfly populations being harmed, but that didn’t pan out. And there are cases where genetic modification of crops had big benefits. For instance, in preserving papaya crops.Much of the Hawaiian papaya crop is genetically modified to protect against a viral blight that almost wiped out crops a decade ago. (It’s not a Monsanto trait, but it is an example of the way this [more...]

Date: 2010-10-13 16:30:12

Senior Software Engineer - SEQanswers

Complete Genomics is an emerging DNA sequencing technology with the promise of high throughput, low cost sequencing of human genomes. The technology has proven itself by sequencing of hundreds of human genomes for customers from research institutions to pharmaceutical giants to clinical researchers. Complete Genomics is aggressively pursuing innovations to aid its customers in the study of human disease and to push its service into vast new markets. It has filed an S1 for IPO. The assembly pipeline team is an amalgam of exceptional bioinformaticians and software engineers of diverse [more...]

Date: 2010-10-01 18:28:02

Shallow Cogitations: The "Born In the USA" DNA Sequence

An article that calls for the analysis of Barack Obama's DNA to settle once and for all the manufactured controversy over his American citizenship. A certificate that a child was born to Stanley Ann Dunham and Barack Hussein Obama in Honolulu on 4 August 1961 might be true; but, assuming it’s true, it does not necessarily follow that Mr. Obama is that child. Whether he is or not requires genetic analysis. Now we have to list all of the possibilities, regardless of how outlandish they are. Assume that Hawai’i’s certification of live birth is true and official as far as it goes. If Mr. [more...]

Date: 2010-10-13 01:10:00

Mutation Rate In Humans Gets Measured By Direct Sequencing

With better measurements of mutation rates, we could improve the calibration of the evolutionary clock, or test ways to reduce mutations, for example. Even with the latest DNA sequencing technology, the researchers had to design a special strategy to search for the vanishingly rare mutations. They used next-generation sequencing to establish the order of letters on the two Y chromosomes and then compared these to the Y chromosome reference sequence. Having identified 23 candidate SNPs – or single letter changes in the DNA – they amplified the regions containing these candidates and [more...]

Date: 2009-08-27 14:01:30

Popular Mechanics Posts 2010 BREAKTHROUGH Awards — The Gadgeteer

While working at the National Institutes of Health in the early 1990s, Venter developed a way to rapidly discover genes by exploiting snippets of DNA called expressed sequence tags. In 1992, he founded The Institute for Genomic Research, and, three years later, he and a team decoded the first genome of a free-living organism. That led to Venter’s best-known breakthrough, mapping the human genome. Last May, he achieved a defining moment in the history of biology when he inserted digitally created DNA into a living bacterium, forming the first synthetic life. His ultimate goal is to design [more...]

Date: 2010-09-28 20:43:25

Job4Dev - Bioinformatics & Machine Learning Expert em DNAnexus ...

DNAnexus is recruiting an expert in bioinformatics and machine learning to help architect and implement the next generation of scalable, intelligent algorithms for DNA sequence analysis. Requirements: Practical experience with Bayesian modeling and inference, machine learning, statistics, and optimization Familiarity with DNA sequence data, Smith-Waterman, BLAST, etc., and the ability to implement the algorithms Comfortable working in distributed environments and architecting parallel algorithms Fluent in C/C++ and understand the implications of your coding style down to the level of machine [more...]

Date: 2010-09-25 13:09:24

Vitamin B12 and body | DNA Sequencing

Vitamin B12 is the vitamin B complex This member of the vitamin B complex keeps cobalt, is also known as cobalamin. This can be discovered, especially in eggs and dairy products and meat. This vitamin is the vitamin as "anti-stress" known. Vitamin B12 is important for the development of red blood cells. It 'also necessary for the cleavage of DNA during cell replication. This vitamin is also essential balance necessary for neurological and Wellnessthe synthesis of myelin. This vitamin also raises the activity of the immune system and helps in the fight against onerous conditions. The [more...]

Date: 2010-10-07 03:00:27

EpiCentral: Examining blocking lesions in ancient DNA

Blocking lesions prevent amplification and sequencing of affected molecules, thus limiting the analysis of DNA derived from ancient samples. Heyn et al. recently developed a new method--polymerase extension profiling (PEP)--that reveals occurrences of polymerase stalling on DNA templates. This sequencing-based technology allows detection of damage on a single-molecule level. The technique used CircLigase™ ssDNA Ligase for high-efficiency ligation of single-stranded adaptors (containing the Roche 454 A sequence) to the 3’ ends of primer-extension products. The authors found evidence of [more...]

Date: 2010-10-07 20:29:00

DNA sequencing » Blog Archive » DNA Sequencing

Structural Biochemistry/DNA recombinant techniques/DNA … DNA sequencing determines the order of Adenine, Guanine, Cytosine, and Thymine within a DNA molecule. … It is one of the simplest techniques when it comes to DNA manipulation. [more...]

Date: 2010-09-28 00:13:44

Nanoscale DNA sequencing technique to advance personalized ...

Nanoscale DNA sequencing technique to advance personalized medicine August 22nd 2010 11:11pm One of the long held hopes for DNA sequencing is that it will usher in an era of personalized, predictive medicine by providing individualized blueprints of genetic predispositions for specific conditions and diseases, such as cancer, diabetes and addiction. Researchers havBy Darren Quick From: [more...]

Date: 2010-08-24 16:16:43

UC San Diego to Lead Personalized Medicine Project on Mood-Stabilizer

The other participating institutions are Indiana University, University of Chicago, University of Iowa, University of Pennsylvania, Johns Hopkins University, University of Michigan, the Translational Genomics Institute in Phoenix, Case Western Reserve University, University of Bergen in Norway, and Dalhouise University in Canada. Research plans call for diagnosing and treating with lithium a total of 700 patients at the ten sites, following the patients’ progress for two years, with a particular emphasis on noting the occurrence of any relapses and the period of time it takes to recover. [more...]

Date: 2010-09-07 17:08:00

Genomics: The next generation | Wellcome Trust

The advent of the Human Genome Project and the development of faster, cheaper DNA sequencing revolutionised medical and biological research - and the technology is still evolving. Mun-Keat Looi looks at the platforms pushing us closer toward the ‘$1000 genome’. At the turn of the millennium, genomics captured the public's imagination with the publication of the first draft of the human genome and the insights it offered into our biology. When the Human Genome Project started in 1991, DNA sequencing entailed laborious radiation-based methods, with researchers manually loading [more...]

Date: 2009-07-28 11:00:00

The Spittoon » My $0.02 about The $1000 Genome

Although Davies generally appears to be a proponent of consumer genomics, he also provides examples of the possible risks of widespread DNA testing in addition to the benefits. While reading this book, I found strong parallels between Davies’ general themes and 23andMe’s overall philosophy. Both Davies and 23andMe stress the importance of “empowering the individual” and “democratizing genetics”.  Direct-to-consumer genetic testing puts the power of knowledge into the hands of the individual, in contrast to what is often deemed the paternalistic nature of the medical [more...]

Date: 2010-10-07 22:16:18

BIVDA.COM - OligoMix® Oligonucleotide Mixture

OligoMix.com LC Sciences provides a unique new tool, OligoMix® enabling low cost, multiplex custom oligonucleotides for various applications serving diverse needs in genomics, proteomics, protein engineering, synthetic biology, drug discovery, and emerging new fields of science such as next-generation sequencing. OligoMix® is a MIXTURE of a large number of DESIGNED synthetic DNA oligonucleotide sequences delivered in a single microtube. OligoMix® is a product developed in response to the need for pooled oligonucleotides used in multiplexing reactions. We synthesize thousands of [more...]

Date: 2010-10-10 21:29:50

DNA sequencing « Home Workout Equipment

Noesis of DNA sequences has become indispensable for basic biological research, other enquiry legs using DNA sequencing, and in numerous applied champaigns such as diagnostic, biotechnology, forensic biology and biological systematics. The advent of DNA sequencing has significantly accelerated DNA Synthesis biological inquiry and discovery. The rapid fastness of sequencing attained with modernistic DNA sequencing technology has been instrumental in the sequencing of the human genome, in the Human Genome Project. Related projects, frequently by scientific collaboration across continents, [more...]

Date: 2010-10-12 16:39:33

UC Davis News & Information :: Brain Gene Shows Dramatic ...

In a computer-based search for pieces of DNA that have undergone the most change since the ancestors of humans and chimps diverged, "Human Accelerated Region 1" or HAR1, was a clear standout, said lead author Katie Pollard, assistant professor at the UC Davis Genome Center and the Department of Statistics. "It's evolving incredibly rapidly," Pollard said. "It's really an extreme case." As a postdoctoral researcher in the lab of David Haussler at UC Santa Cruz, Pollard first scanned the chimpanzee genome for stretches of DNA that were highly similar between chimpanzees, mice and rats. Then [more...]

Date: 2006-08-16 07:00:00

Biomarker Validation Aging: Lessons mtDNA Heteroplasmy Analyses Early

2173 Article Views Authors: Peter E. Barker and Mahadev Murthy Publication Date: 27 Nov 2009 Journal: Biomarker Insights 2009:4 165-179 Abstract The anticipated biological and clinical utility of biomarkers has attracted significant interest recently. Aging and early cancer detection represent areas active in the search for predictive and prognostic biomarkers. While applications differ, overlapping biological features, analytical technologies and specific biomarker analytes bear comparison. Mitochondrial DNA (mtDNA) as a biomarker in both biological models has been evaluated. However, [more...]

Date: 2009-11-27 01:47:09

Junk DNA and Complexity Science: A Sad mix

A quote from an extremely mediocre book, Complexity: A Guided Tour. Like most people coming out of the 'complexity sciences', the author has a mediocre grasp of molecular biology, both current developments, and the history of the field. It's frustrating that these network people keep hyping supposedly new revolutionary discoveries made the past 10 years of the genome era - discoveries, that in fact have been known for decades. For people clearly new to biology, molecular biology before the year 2000 was a big black hole of ignorance. There are several claims that make me angry in this book, [more...]

Date: 2010-05-21 19:56:10

Mitochondrial DNA Genealogy

The mitochondrial DNA genealogy is the study of a person’s mother’s family line of maternal ancestors. This DNA is passed down from mother to each of her children exactly as she has it, with no mutations, except in the very rare instances. Because of the traditions in our society of the wife taking her husband’s last name, a surname genealogy trace of the female line of the family tree is more difficult. On the flip side, since this DNA strand is more stable than the Y DNA, more conclusive results can be determined for the testing of it. The mt-DNA is sometimes referred to as the Full [more...]

Date: 2010-10-05 09:25:26

What Does DNA Stand For in Science | Intelligent Mag

Before cells are divided, the chromosomes duplicate first; this is what we call replication of DNA. This is the division of cells which results in two cells that have to contain the same information like their mother-cell. There are four nitrogenous bases within the DNA molecule. Those are: Adenine, Cytosine, Thymine and Guanine. Genes are composed of bases. In case of DNA damaging, the sequence of DNA will be changed. This happens when there is mutagen factor involved. These mutagens are highly radioactive. The damage that occurs as a result of the radiation is determined by the mutagen [more...]

Date: 2010-10-09 19:47:49

A.E.Brain: ADHD, Genes, and Neurology

In children without ADHD, about 7 percent of them had deleted or doubled chromosomes in the analyzed gene sequence. But among children with the disorder, researchers discovered about 14 percent had such genetic alterations. Scientists also found that 36 percent of children with learning disabilities in the study had the chromosomal abnormalities, compared to those with a normal IQ. "This is the first time we've found that children with ADHD have chunks of DNA that are either duplicated or missing," said Anita Thapar, a professor at the MRC Centre in Neuropsychiatric Genetics and Genomics at [more...]

Date: 2010-10-08 11:44:00

Free molecular biology software for Macs | Bioinformatics Blog

Posted on the October 12th, 2010 under Free mac software by bioinformatics-blog 1. Serial Cloner Serial Cloner is fantastic all-in-one workbench; import and manipulate sequences, construct plasmid and restriction site maps, determine %GC and fragment TM, extract and ligate fragments, perform virtual PCR… and lots more, all in one window using a very intuitive graphical interface. 2. 4Peaks 4Peaks is an extremely user friendly DNA sequence chromatogram viewer and editor from the extremely talented guys at Mekentosj. It’s miles better than any of it’s clunky counterparts… try it, [more...]

Date: 2010-10-12 11:08:47

Bio Saga Blog: 5-Day Hands-on Workshop on Molecular Biotechnology ...

Recombinant DNA Technology: Cutting & pasting of DNA molecules (i.e. restriction digestion, ligation, DNA gel eectrophoresis, and gel extraction.) Bioinfo part: Bioinformatics of DNA database / SequenceAnalysis: Pairwise sequence alignment, Multiple sequence alignment, Pattern search.Tools: BLAST, CLUSTALW/X, CLC Bio Main Workbench Genetic Engineering: Transformation and plasmid purification, cloning and sub-cloning, amplification of DNA fragments by polymerase chain reaction (PCR). Bioinfo part: Designing of PCR primers In-silico cloning Searching for homologous and paralogous [more...]

Date: 2010-09-29 05:41:00

Keiichi Itakura Biography, life and Career Facts, Invented

After completing his doctoral work, Itakura received a fellowship to study DNA synthesis under Dr. S. Narang at the National Council of Canada, located in Ottawa. Itakura found DNA synthesis to be a compelling field of research and was interested in learning more about the recently discovered synthesized gene of transfer ribonucle-ic acid (t-RNA), which had been found by the Indian-born American biochemist HAR GOBIND KHORANA. After his fellowship ended, Itakura went to the California Institute of Technology in Pomona to work as a senior research fellow. In 1975 Itakura joined the staff of the [more...]

Date: 2010-09-30 10:10:52

Do you want to live forever? Scientist may have figured out how…

The ends of the chromosomes are capped by telomeres, long thought to have a protective function. Without them, the chromosomes would be shortened during each cell division, because DNA polymerase is unable to copy to the very end of one of the two DNA strands it is replicating.       In the early 1980s, after their fortuitous meeting at a Gordon Research Conference in 1980, Blackburn and Szostak discovered that telo­meres include a specific DNA sequence. Fired up by the novelty of each other's work, they devised experiments that seemed crazy at the time, even to themselves. Szostak took [more...]

Date: 2010-10-05 10:21:00

Lab Tech / Research Associate (Torrey Mesa) | PCR Jobs

Candidate must be familiar with basic molecular biology techniques such as DNA purification, DNA gel electrophoresis, restriction digestion, PCR including primer design, plasmid construction, DNA sequence analysis software and bacterial transformation. Candidate will also assist with sample receipt and tracking, maintain inventory and equipment, and perform general lab maintenance and cleaning to include handling of biological waste. Education/ Skills/Attributes Required: · Must be a US Citizen. · BS degree in biology/biochemistry with 0-3 years industrial experience. · Experience with [more...]

Date: 2010-10-12 19:15:31

DNA sequencing » Blog Archive » DNA Sequencing Methods

DNA Sequencing – How DNA Sequencing Works – Methods for … An explanation of how DNA sequencing works. … Typically, the automated sequencing method is only accurate for sequences up to a maximum of about 700-800 base-pairs in length. … DNA Sequencing Simulation (Sanger Method) Within each reaction mixture are the following items: a DNA segment of unknown … The other DNA sequencing method (named for Allan Maxam and Walter … Next-Generation DNA Sequencing Methods 921k – Adobe PDF – View as html generation DNA sequencing technologies highlight the striking impact … [more...]

Date: 2010-09-28 04:29:58

An Epigenetic Mountain for Ovarian Cancer Research « Promega ...

Epigenetic regulation of gene expression is heritable, and refers to changes in gene activity that do not involve alterations to the primary DNA sequence, but rather modifications to the DNA molecule itself or to the chromatin structure. Identifying a gene involved in chromatin/nucleosome structure as a major player in cancer is important, because although epigenetic changes are prevalent in many cancer types, the relationship between the genetic changes and the epigenetic profiles of tumors is not well understood. The identification of genes directly involved in chromatin remodeling, histone [more...]

Date: 2010-10-08 13:17:45

Dienekes' Anthropology Blog: mtDNA of Yemeni and Ethiopian Jews

The way I see it, only a large-scale study of all global Jewish populations may uncover verified ancient Jewish lineages for both Y-chromosomes and mtDNA. The recent studies on Jews have uncovered several genetic sub-clusters of Jews, and only lineages that occur in 2 or more of these clusters, and preferably geographically separated ones have a strong claim of representing original Jewish lineages. There is a limit on what can be uncovered about the past from the study of living populations. American Journal of Physical Anthropology doi: 10.1002/ajpa.21360 Mitochondrial DNA reveals distinct [more...]

Date: 2010-07-14 18:00:00

Ancestry DNA testing in Australia

You will be connected genetically to perhaps such groups as Sub-Saharan, Native American, East Asian or European. Some terms you will come across in your ancestry DNA test: Mutations in DNA A mutation is a permanent change in which the DNA sequence is somehow altered; with these changes come actual changes to the person or to traits. A very short note on mutations; mutations are of course not always harmful- some mutations are very important and very beneficial and enable us and enabled our ancestor to survive in the conditions they lived. Haplotype: A Haplotype is a group of closely linked [more...]

Date: 2010-08-13 10:30:52

New Technique for DNA Sequencing with Speed and Low Cost

The new research is an important step towards the sequencing of DNA cheap (costing a thousand dollars or less per genome). In 2004, cost about $ 10 million to sequence a genome similar in size to a human. Tags: alabama university research, dna sequencing, nanopore This entry was posted on Tuesday, October 5th, 2010 at 5:30 am and is filed under Biotechnology. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own [more...]

Date: 2010-10-05 11:30:51

Darwin's God: For What Profit?

But paternity testing and DNA fingerprinting are completely unrelated to the pseudogene example presented by evolutionist Ken Miller at the Kitzmiller trial. This comparison of forensic tests with evolutionary homologies is another common evolutionary canard that evolutionists use to mislead those not familiar with molecular biology. Forensic tests are performed where genealogical relationships are known to exist because they are empirically observed. There’s no question that people have children, and those children’s DNA sequences derive from their parents, grandparents, and so forth. [more...]

Date: 2010-10-13 08:50:00

Artwork based on DNA sequencing offers unique décor options for ...

“This ingenious service is truly personalized: the resulting artwork from an individual’s DNA will be like no other anywhere and in any time. Moreover, the fact that portraits based on DNA sequencing do not comprise human imagery will be an added attraction in the Arab world, and we can certainly expect this new kind of art form to adorn the walls of many homes here. Also, with the UAE and more specifically Abu Dhabi now promoting art and culture in a big way, as reflected by the development of five art and culture centres within its Saadiyat Island at present, DeScript will definitely [more...]

Date: 2010-09-20 03:00:38

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