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Chemical synthesis of the mouse mitochondrial genome « too New to yoU

However, this study used the basic synthesis unit is a nucleotide containing thousands of DNA (deoxyribonucleic acid) fragments. Because the basic synthesis unit larger, the final synthesis in the verification is correct the genome will bring some trouble. Thus, the research team invented a new method of synthesis of the genome, using the basic synthesis unit is only 60 nucleotides of DNA containing fragments, placing them well-designed environment, you can connect into the whole genome. The group believes that this is by far the easiest way to synthetic genome. In order to verify the [more...]

Date: 2010-10-13 07:19:52

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Break Out the Brazil Nuts -- You Need More Selenium - thatsfit.ca

Along with other antioxidant nutrients, selenium helps to block reactions that lead to free radical formation; free radicals which can cause DNA mutation leading to cancer. Glutathione peroxidase is one of the body's most powerful antioxidant enzymes, used by the liver to detoxify a wide range of potentially toxic molecules. Selenium also protects against cancer by inducing DNA repair and synthesis in damaged cells, repairing free radical damage that has already occurred. It inhibits the spread of cancer cells and induces tumor cells' natural self-destruct sequence. Plus, selenium is [more...]

Date: 2010-09-27 18:00:00


Purdue Newsroom - Purdue professor wins Nobel Prize in chemistry

Examples of applications include drug manufacturing, fluorescent marking that has been essential for DNA sequencing and creating materials for thin LED displays. He discovered catalytic reactions using a number of transition metals that allow various organic compounds to be synthesized widely, efficiently and selectively for use in fields ranging from medicine to materials development. His work has resulted in dramatically reducing the cost of using such metals, like palladium, in the synthesis. "Catalysts are not lost as they spur a chemical reaction, they are recycled and can be used over [more...]

Date: 2010-10-06 20:05:13


DNA strides into organic synthesis

The walker and three 'stations', made from specific DNA sequences, organise themselves along the track using the normal pairing of DNA bases. 'The walker will move unidirectionally along the track,' Liu says. 'We attached chemical reactants to the walker and each station on the track. As the DNA walker moves from station to station, a programmed series of chemical reactions takes place.' The walking strand of DNA moves to each station (blue, red and green) in turn and reacts with the attached reagent © Nature Nanotechnol. In this way, the Harvard team was able to perform three acylation [more...]

Date: 2010-10-10 22:46:00


The Aspergillus Website blog: New Research to Help Identify ...

those that target DNA/RNA synthesis e.g. flucytosine. Mammalian cells make extensive use of DNA & RNA so this drug lacks specificity. Difficult to use. Clearly the best existing target in terms of specificity is the cell wall. In this news report it states that this research group have just announced the $1.5 million funding of new research into drugs that will act on a component of the construction of cell walls (UDP-galactopyranose mutase) in fungi with the aim of disrupting the process and thus making it very difficult for the fungus to make its own cell wall and grow normally. This [more...]

Date: 2010-09-29 10:13:00


DNA art imitates life: Construction of a nanoscale Mobius strip

The circulations of earth's warmer and cooler ocean currents for example, describe a Möbius shape. Other topological structures are common to biological systems, particularly in the case of DNA, the 3 billion chemical bases of which are packed by the chromosome inside the cell, using topological structures. "In bacteria, plasmid DNA is wound into a supercoil," Yan explains. "Then the enzymes can come in and cut and reconfigure the topology to relieve the torsion in the supercoil so that all the other cellular machinery can have access to the gene for replication, transcription and so [more...]

Date: 2010-10-08 21:50:00


Medicine: New factor required for hepatitis C infection

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis DOI: 10.1038/nsmb.1927 Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3 DOI: 10.1038/nsmb.1919 Structural polymorphism in F-actin DOI: 10.1038/nsmb.1930 ******************************************************************************** GEOGRAPHICAL LISTING OF AUTHORS The following list of places refers to the whereabouts of authors on the papers numbered in this release. The listing may be for an author's main affiliation, or [more...]

Date: 2010-10-11 19:28:59


Welcome to Sage

Synthetic genomics is the chemical synthesis of DNA sequences. The synthesized sequences can already exist – as in the chemical synthesis of genes naturally found in an organism – or it can involve the synthesis of novel, unnatural DNA sequences. Synthetic biology is both the design and construction of new biological parts, devices, and systems and the redesign of existing natural biological systems for useful purposes. Because the synthetic life sciences may enable the synthesis of biomolecules, whole genomes, and even simple life forms, these sciences have enormous potential, as they [more...]

Date: 2010-09-16 13:18:45


Species Nutrition Isolyze, Chocolate Milk, 4-pound Tub

This procedure has the added benefit of preserving 3 valuable components of whey immunoglobins, lactoferrins, and glycomacropeptides that are necessary for optimal immune system function and protein synthesis reactions. And if all this werent enough, ISOLYZE tastes great too! Gone are the days of the chemical- or sour-tasting whey isolates! With ISOLYZE, you get the best of both worlds great quality and great taste! List Price: $ 99.99 Price: $ 63.70 Vegan Sublingual B-12 – 90 tabs,(Deva Nutrition) Category: Vitamin B & B Complex Low Carb, Low Sodium, Dairy Free, Gluten Free, Vegan, Wheat [more...]

Date: 2010-10-12 07:29:47


Microsoft Research Makes Microsoft Biology Foundation and ...

MBF implements a range of parsers for common bioinformatics file formats; a range of algorithms for manipulating DNA, RNA and protein sequences; and a set of connectors to biological Web services such as National Center for Biotechnology Information BLAST.“Biologists face a number of issues today, such as detecting correlations between human genome sequencing or identifying the likelihood for a patient to develop a certain disease,” said Tony Hey, corporate vice president of Microsoft External Research. “The MBF aims to provide healthcare research facilities with the tools needed to [more...]

Date: 2010-10-13 12:28:03


Nobel season '10: Chemistry

I've also seen that different large-scale DNA-sequencing approaches, primarily shotgun sequencing, are on the map in Swedish media which I think is really strange. Firstly because Fred Sanger, who developed shotgun sequencing, is 92 years old and a double Nobel laureate in chemistry already (1958 and 1980), and secondly because the field of large-scale sequencing still hasn't peaked by any means. Perhaps Leroy Hood (again) could be considered for the development of the first automated DNA sequencer? Anyway, the technologies that are advancing the field have been developed by private companies [more...]

Date: 2010-10-06 07:00:00


Active Site Mutations in Mammalian DNA Polymerase {delta} [Enzymology]

Active Site Mutations in Mammalian DNA Polymerase δ Alter Accuracy and Replication Fork Progression* Michael W. Schmitt‡, Ranga N. Venkatesan§, Marie-Jeanne Pillaire¶, Jean-Sébastien Hoffmann¶, Julia M. Sidorova§ and Lawrence A. Loeb‡§,1 From the Departments of ‡Biochemistry and §Pathology, University of Washington School of Medicine, Seattle, Washington 98195 and the ¶Genetic Instability and Cancer Group, Institute of Pharmacology and Structural Biology, CNRS and University of Toulouse, 31077 Toulouse, France 1 To whom correspondence should be addressed: University of [more...]

Date: 2010-10-08 13:45:11


Whatever Is in Aloe Vera Juice : Minuteman Fire Protection

It has an effect on the synthesis and regulation of DNA, as well as energy production and synthesis of fatty acids. If the body lacks this nutrient, it can cause Pernicious Anemia and Megaloblastosis. This is one of the reasons why aloe juice is sometimes recommended as a natural remedy for the aforementioned ailments. The distribution of iodine in the body can be found with seventy percent in various tissues such as the eyes, cervix, gastric mucosa, mammary glands, as well as the salivary glands. In order for the thyroid to synthesize the required daily amounts of Thyroxine and [more...]

Date: 2010-10-13 14:27:29


Life Technologies Licenses DNA Technology

According to Life, the technology it is licensing increases the accuracy and pace of research in the field of synthetic biology. Novici's technology is used to detect and correct errors in DNA synthesis or during PCR [more...]

Date: 2010-10-11 12:21:00


Alnylam Scientists Present New Data on RNAi Therapeutics at ...

Further, several of the presentations describe the design, synthesis, and analytical characterization of siRNAs with optimized properties, including: “Solid-phase synthesis of 5'-di- and tri-phosphates and their modified analogs of DNA, RNA and chemically modified oligonucleotides,” by Ivan Zlatev, Ph.D., Scientist; “Parallel high throughput synthesis of chemically modified 21-27mer siRNA sequences,” by Satya Kuchimanchi, Ph.D., Associate Director, Small Scale Synthesis; “Novel method for the confirmation of siRNA sequence by LC-MS/MS,” by Gary Lavine, Ph.D., Senior [more...]

Date: 2010-08-24 12:13:50


Ch. 14 Vocabulary: DNA: The Genetic Material

DNA Polymerase Epsilon: (pol ε) Part of the complex of the main replication polymerase used in eukaryotic organisms. DNA Polymerase Delta: (pol δ) The other part of the complex of the main replication polymerase used in eukaryotic organisms. Telomere: A specialized nontranscriptional structure that caps each end of a chromosome. Telomerase: An enzyme that synthesizes telomeres on eukaryotic chromosomes using an internal RNA template. Mutagen: An agent that induces changes in DNA (mutations); incluyes physical agents that damage DNA and chemicals that alter DNA bases. Thymine Dimer: Formed [more...]

Date: 2010-03-10 06:05:00


Reconstructing human appearance from DNA -- Signs of the Times News

This is a relatively robust, but not foolproof, gender test, according to Kayser. Hair colour prediction underway Beyond gender, the human traits with highest predictive accuracy are those affected by pigmentation, simply because they are the least complex. Red hair colour, which is determined by a single gene, can be predicted with a certainty of around 93%. For other hair types, accuracy is slightly lower, but still promising. Kayser reported confidence levels as high as 85, 81 and 80% for predicting black, brown and blond hair respectively. Perhaps the most progress has been made in [more...]

Date: 2010-09-28 13:51:40


Clean Genes: Michigan Tech Chemist Culls the Good Synthetic DNA ...

Synthetic DNA purification process developed by Shiyue Fang, Michigan Tech Chemistry Department image July 22, 2010— Birds do it, bees do it. Even scientists in labs do it. But the scientists can’t hold a candle to the birds and the bees, who can make gobs of primo DNA without even thinking about it.DNA is a critical element of gene therapy, and scientists working to develop cures for diseases make it with synthesizers. Unfortunately, synthesizers don’t do nearly as good a job as cells in stringing nucleic acids together to make DNA, and many of the resulting sequences—called [more...]

Date: 2010-07-22 19:46:37



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