Pitt Chronicle » Blocking DNA Repair Protein Could Lead to ...
Patients carry a gene mutation that stops production of a protein called ATM kinase, which spurs other proteins involved in normal cell division, DNA repair, and cell death. Radiation causes DNA mutations during the process of cell division, when genetic material is copied for a new cell to form. The cell has repair pathways that include checkpoints to look for errors as well as methods to repair them, but if enough mutations accumulate, the cell could become cancerous or self-destruct. A-T patients, who lack the kinase, have a higher risk for developing cancer, Bakkenist said. Bakkenist and [more...]
Date: 2010-10-04 11:20:21
Popular Mechanics Posts 2010 BREAKTHROUGH Awards — The Gadgeteer
While working at the National Institutes of Health in the early 1990s, Venter developed a way to rapidly discover genes by exploiting snippets of DNA called expressed sequence tags. In 1992, he founded The Institute for Genomic Research, and, three years later, he and a team decoded the first genome of a free-living organism. That led to Venter’s best-known breakthrough, mapping the human genome. Last May, he achieved a defining moment in the history of biology when he inserted digitally created DNA into a living bacterium, forming the first synthetic life. His ultimate goal is to design [more...]
Date: 2010-09-28 20:43:25
Think Out Loud Sizing Up Your Genes · Oregon Public Broadcasting
Now, a host of startup companies are selling at-home kits that promise to unlock the secrets of customers' DNA in a matter of weeks. Intel employees, who get a discounts from two genetic testing companies, use the tests to reveal their genetic predisposition to everything from cancer to cellulite. But many in the medical community are skeptical of the tests' legitimacy, and the U.S. Government Accountability Office recently released a report calling the tests "misleading" and accusing the companies administering them of "questionable practices." Have you elected to use genetic testing? If [more...]
Date: 2010-08-11 16:00:00
The best way to Detect and Stop Cervical Cancer
Screening tests embrace both standard Pap smear or liquid cytology, with or without HPV (human papilloma virus) DNA test. The current recommendations from the American Faculty of Obstetricians and Gynecologists for regular-risk ladies are as follows: 1) Pap smear to begin at age 21 2) 30 years of age: every three years 4) Cease screening at age 65-70, after three regular tests during the last 10 years. Screening is more frequent for prime risk women. Excessive risk circumstances embrace previous cervical cancer, publicity to DES (diethylstilbestrol) as a fetus, and immunocompromised [more...]
Date: 2010-10-09 16:52:28
Genetic Test Kits-Journey Down the Rabbit Hole | generationhealth.com
A recent news story about the FDA’s halt to the sale of genetic test kits at Walgreens and CVS has opened the door to a public discussion on the issue of gene mapping and genetic testing. For instance, is this a case of science moving at such a fast pace that social policy and ethical determinations have not had a chance to catch up? Many think so. Testing genes within DNA for mutations that are associated with specific diseases has many ramifications that need to be addressed before such technology is used outside the realm of scientific exploration and discovery. One of the big issues [more...]
Date: 2010-07-08 17:43:21
Law and Biosciences Blog | Should Mary Carmichael Get DTC Genetic ...
Mary Carmichael at Newsweek is running an interesting week-long series of posts about deciding whether or not to buy DTC genetic testing for herself. Carmichael series She asked me to contribute an “about 300 word” post on “How do I know if I can trust the results and should I be worried about what I might find out?” Monday, I sent her both a 389 word version and a 300 word version. Tuesday, she sent me back a 308 word version for posting, which I accepted. Today (Wednesday), the Newsweek site has posted a 230 word version. Carmichael: Day 3 It captures much of what I wanted to [more...]
Date: 2010-08-04 17:22:14
Stool DNA test for colon cancer not yet cost-effective
Stool DNA test for colon cancer not yet cost-effective The inexpensive stool tests commonly used to screen for colon cancer can be more effective, and much less costly, than newer tests that look for certain genetic markers in the stool, according to a study published Monday. Read more on Reuters via Yahoo! News Breast cancer patient claims discrimination Agent apparently tells woman that her breast cancer medications could make her incapable of understanding and signing a one-year lease. Read more on Seattle Times AccuQuote Reports Gender-Specific Cancers May Not Affect Life Insurance [more...]
Date: 2010-09-21 09:31:01
Coralville's IDT Partners with Marshall University
The Marshall Institute for Interdisciplinary Research (MIIR) has announced it has entered into an applied research and product development partnership with leading biotechnology company Integrated DNA Technologies (IDT). According to the terms of the agreement, scientists at MIIR will be developing optimized biomolecular analyses or “assays” to be used by IDT for the detection and quantification of ribonucleic acid (RNA). The goal of the co-development project is to significantly improve the specificity of IDT’s current assay methods without substantially increasing the cost. IDT’s [more...]
Date: 2010-05-21 20:59:12
Biologists Tackle Cells' Identity Crisis
The group has now developed and tested a standardized procedure for extracting DNA from cells, doing the fingerprinting and interpreting the results.“Without policing, many investigators may not be motivated to do the necessary tests.” Many researchers already use DNA fingerprinting to test their cell lines, notes Steve Oglesbee, director of the tissue-culture facility at the Lineberger Comprehensive Cancer Center of the University of North Carolina in Chapel Hill. The ATCC and other repositories have already established fingerprints for some of the most commonly used lines. "We're [more...]
Date: 2010-06-07 13:52:00
Walgreens Postpones Sale of Genetic Testing Kit
Mere days after announcing plans to sell the first over-the-counter genetic testing kit at 6,000 locations, the nation’s largest drugstore chain has reversed course. Walgreens, which operates 7,500 retail outlets across the country, is holding off on stocking the tests because of concerns expressed by the Food and Drug Administration in an open letter to the company that makes the product. On Tuesday, Pathway Genomics, a San Diego-based start-up that already sells genetic tests online, announced that the product, called Insight, would be available at Walgreens locations starting May [more...]
Date: 2010-05-13 17:45:18
Metastatic Breast Cancer – Causes, Symptoms and Treatment | Breast ...
MammaPrint adversity is the formerly tests with the intention of became individual of the formerly breast evil predicator, which won the smart good opinion of the USFDA. This is a new to the job form of DNA test, which willpower predict whether women together with the first period of evil desire exchange popular on the subject of 5 headed for 10 years. This investigation willpower stop headed for encouragement taking place how belligerently the lump clothed in the preliminary stages bottle be real treated. ILT (Interstitial Laser thermotherapy) is individual of the innovative methods with [more...]
Date: 2010-10-10 05:31:24
The cancer holy grail: DNA test will allow doctors to create ...
The researchers at Johns Hopkins took six sets of cancerous and normal tissue from four bowel and two breast cancer patients and “sequenced” – or decoded – the complete set of DNA for each patient. By comparing DNA from healthy and cancerous tissue, the researchers could spot where large parts of genetic code had been altered. These changes occur only in cancer cells, making them ideal biomarkers for the disease. Once the researchers found areas where DNA had been rearranged, they looked for the same changes in DNA shed from tumours into the patients” blood. Using blood samples [more...]
Date: 2010-09-29 21:36:09
deCODE receives California Clinical Laboratory License
Our competitors outsource the science, the DNA-analysis, or both. But for us this is the real foundation of personalized medicine, and we are committed to delivering only the best validated tests and the highest quality results, all in-house. We are pleased that Californians will now be able to benefit from the highest quality products in this exciting new field,” said Kari Stefansson, CEO of deCODE. Through its reference laboratory testing service, www.decodediagnostics.com, deCODE offers DNA-based tests for assessing individual risk of heart attack, type 2 diabetes, breast cancer, [more...]
Date: 2009-02-19 18:14:45
DNA genetic testing: New rules on genetic testing services
New safeguards are to be introduced for genetic testing services to protect people from what the government calls “false reassurances” about their future health. The rapidly expanding industry offers test kits direct to patients, usually cutting out doctors and follow up care and support. Screening is available online for conditions like Huntington’s and breast cancer, yet so far these businesses have not been regulated. Little basis in science The Department of Health says many companies are now offering to test large numbers of genes whilst making claims that the tests will allow [more...]
Date: 2010-08-04 00:06:49
Ultrasound for the diagnosis of breast cancer » Nano Bio Technology
Al Esma Congress (European Society for Medical Oncology) course in Milan has been made a new molecule that could become a new weapon against certain forms of breast cancer. These are molecules that carry the drug directly into tumor cells. The drug, called T-DM1 consists of two components, that together make it extremely effective: Trastuzumab, a monoclonal antibody already used successfully in the fight against the form of HER2-positive breast cancer (most common in Italy), and DM1, substance known for some time but very toxic to the body and are not used in therapy. The antibody carries [more...]
Date: 2010-10-13 07:40:35
How 23andMe Saved My Wife - jonsteinberg
Jon Steinberg is the President of BuzzFeed in NYC.He was previously Strategic Partner Development Manager on Google's SMB (Small Medium Business) Partnerships team.Prior to Google, Jon was the Director of Business Development at Majestic Research and the founder of iBuilding, a commercial real estate software company backed by Tishman Speyer Properties, Benchmark Capital, and 12 Entrepreneuring.He is a graduate of Princeton University's Woodrow Wilson School of Public and International Affairs and holds an MBA from Columbia [more...]
Date: 2010-10-12 13:42:28
Biochemical disorders induced by cytotoxic marine natural products ...
Biochemical disorders induced by cytotoxic marine natural products in breast cancer cells as revealed by proton NMR spectroscopy-based metabolomics. ... BioNMR stuff: Feedback, suggestions, requests · Announcements · Test forum [more...]
Date: 2010-10-12 14:52:01
Walgreens Releases At-Home DNA Test | Gather
views: 601 | 1 person recommends this | comments: 1 Walgreens and San Diego-based company Pathway Genomics have partnered together to unveil an at-home DNA test. The test retails for between $20-30 dollars, and is non-invasive, requiring only a swab of saliva to complete. The test is designed to assess the users risk of developing certain inherited diseases, such as breast cancer or Alzheimer's disease. It can also tell the person certain information regarding their risk of passing on genetic defects, such as cystic fibrosis.In a society where digital pregnancy tests address the [more...]
Date: 2010-05-12 03:04:27
Home Genetic Testing for Alzheimer's?
That fact is even more important now that Walgreens is close to selling a home genetic testing kit that the Washington Post reported on Tuesday can scan genes for a propensity for Alzheimer's disease, breast cancer, diabetes and other ailments. The testing kit, marketed by Pathway Genomics, involves sending in a saliva sample to produce a DNA sample that is tested for genetic markers. The FDA acted quickly in criticizing the kit as lacking in safety, efficacy, and accuracy, and Walgreens announced yesterday that is postponing sales of the kit. In Alzheimer's disease, genetic testing is only [more...]
Date: 2010-05-13 16:50:02
DNA Check, Aisle 4: Walgreens to Sell Pathway's Genetic Test ...
Are consumers ready for an over-the-drugstore-counter test that claims to evaluate their odds of developing chronic diseases, becoming obese or having a child with a genetic defect? Pathway Genomics is betting they are, the Washington Post reports. The company plans to sell its Insight genetic test — which costs $20 to $30 for the initial kit plus as much as $249 more, depending on what information the purchaser wants to find out — in about 6,000 Walgreens stores. Consumers send their saliva off to a lab and can opt to have their DNA analyzed for their risk of diseases and conditions [more...]
Date: 2010-05-11 14:30:32
Pathway Genomics and Walgreens debut OTC DNA testing - Gather News ...
Pathway Genomics will release a personalized DNA testing this Friday. The over-the-counter DNA kits will be sold at Walgreens across the nation. Pathway Genomics is a company out of San Diego that already has home genetic testing kits available.To use the kit, consumers use ‘spit’ to get their results. Supposedly the DNA kit will let you know if you have a genetic risk for Alzheimer’s, diabetes or breast cancer. You can also find out if you might be able to pass on a disorder like cystic fibrosis. The kit at Walgreens will retail between $20-$30.The FDA does not regulate these tests at [more...]
Date: 2010-05-12 04:02:34
The Mermaid's Tale: Direct-to-consumer genetic testing -- again
have increased greatly in living memory. That's environment, not genes! Even breast cancer risk fluctuates, even for people with the high risk alleles, depending on when a carrier was born. Genetic effects depend on context. Yet knowing as we do that the effect of context can change we know that we don't know the future environmental exposures -- and hence the future risks associated with the same genotypes. Many or most DTC risk estimates are, quite literally, passé. So, again as we've said before, regulation of what these companies is selling is a legal issue that must be [more...]
Date: 2010-10-12 09:35:00
Over the Counter DNA Kits to Be Released Friday
Forget going to the doctor! There's a new over the counter test kit you can buy to see If you're likely to develop conditions or diseases like breast cancer or diabetes. Starting Friday Walgreens will become the first U.S. retailer to sell test kits for $30 dollars. Other companies sell DNA test kits online but pathways is the first to do so in stores. The FDA says all DNA test kits come under its jurisdiction and without approval, pathways could face legal trouble. The kits promise customers information about their risk for developing diseases and passing conditions to their unborn [more...]
Date: 2010-05-11 23:45:15
FDA, Walgreens Puts Pathway Genetic Test Sales on Hold
FDA, Walgreens Puts Pathway Genetic Test Sales on Hold Walgreen’s drug stores originally had plans to launch the retail sale of an at-home genetic test on Friday that allows the consumer to assess his or her risk for diseases such as breast cancer, heart disease, and Alzheimer’s. The nation’s largest drugstore chain has opted to put sales on hold after an FDA warning that the test is not approved and could put consumers at risk. The test requires FDA authorization because it involves a device that allows consumers to collect their own DNA. The agency is also concerned about the fine [more...]
Date: 2010-05-13 12:20:02
Home DNA Tests: Proposed New rules : : Healthcare News
A set of new rules and guidelines have been put forward by Human Genetics Commission (HGC) to crack down on inaccurate and harmful home do-it-yourself DNA tests freely sold over the internet. Many private companies, based mainly in the US, offer such direct to consumer testing kits that estimate a person’s risk of suffering from diseases like Alzheimer’s or breast cancer, by analyzing the genetic codes. Paternity testing or finding out the identity of the father is another reason as to why these tests are gaining in popularity. The Commission has expressed its reservations about [more...]
Date: 2010-08-31 12:02:53
autism center of pittsburgh – Do Cell Phones Really Cause Cancer ...
Drs. Singh and Lai reported a decade ago that cell phone radiation quickly causes DNA single-strand and double-strand breaks at well below the current federal safety level for exposure. This causes a condition called micronuclei. Dr. George Carlo is a public health expert who conducted wireless technology research. He showed that human blood exposed to cell phone radiation had a 300% increase in genetic damage in the form of micronuclei. He says that wireless technology is “potentially the biggest health insult” this nation has ever seen, bigger than cigarette smoking and asbestos. Even [more...]
Date: 2010-10-13 13:00:17
Ovarian Cancer Diagnostics | Ovaire
DNA testing reagents for cancer CTC Test markets Biochip Innovations New companies with new approaches "Laggards" Companies that have not met expectations Protein important molecular markers used in tissue staining Biomarkers under investigation Mergers and Acquisitions Status of pharmacogenomic tests Microarrays Markets in clinical laboratories The lists of suppliers and main products Unmet market needs This report includes market analysis of the following tests: The Profile Cancer CTC, fecal occult blood, PSA, H. pylori, IHC, ISH, and evidence of specific cancers: Bladder [more...]
Date: 2010-10-11 18:38:23
True Health Is True Wealth!!: Walgreen's New DNA – At-Home Genetic ...
Freak yourself out with new at-home genetic testing kit » 11:17 AM PT, May 12 2010 Attention hypochondriacs! If you are feeling the need to seriously freak yourself out, look no further than your local Walgreens store! Yup, starting Friday you can purchase an at-home test kit that allows people who, well, worry about these things (obsessively) to see if their DNA makes them more likely to develop one (or more!) of dozens of different health conditions. Breast cancer? Check. Heart disease? Check! Alzheimer's disease? Can do! Just swab your cheek, pop it in the mail and within a week or so, [more...]
Date: 2010-05-12 21:00:00
Government moves to oversee at-home genetic tests - Chicago ...
The FDA first signaled a possible shift in direction after another firm, Pathway Genomics, last month moved to sell genetic test kits through Walgreens drugstores. The plan was quickly shelved, but a high-profile congressional committee launched its own investigation. The tests prompting attention are not the highly specialized DNA scans ordered by physicians. Instead, these consumer-oriented offerings evaluate an individual's risk of developing various illnesses or responding variably to different medications, based on test findings. That is problematic because most of the genetic [more...]
Date: 2010-06-15 01:08:00
Genetic DNA Testing for Breast Cancer
pay per click advertising Genetic test which is also known as DNA-based test is the most powerful technique used to test for breast cancer detection. It involves the direct examination of DNA molecule itself. [more...]
Date: 2010-08-23 23:59:04
Genetic Testing at Walgreens – the First Wave of Personalized ...
Soon you may be able to buy genetic testing kits at your local Walgreens, Pathway Genomics announced this week. The kits include directions on how to send a sample of your saliva back to the company for testing. The initial products will include “individualized Genetic Insight™ Report for Drug Response ($79), Pre-Pregnancy Planning ($179), Health Conditions ($179) or a combination of all three ($249)” according to the company. Are these kits reliable? What do you do with the information? The reliability of such tests depends upon the depth of understanding of our genetic “blueprint” [more...]
Date: 2010-05-14 14:21:42
Dr. Rick Kittles (Part 2) Full Episode
Kittles talks about the use of DNA to trace a person’s heritage and how he responds to critics of his work. Dr. Kittles’ research focus is to formally evaluate genetic mechanisms involved in complex diseases. His work entails understanding how genetic variation is structured across human populations and how that variation contributes to inter-individual variation in disease susceptibility and other phenotypes such as drug response and skin color. Currently his work explores sequence variation within candidate genes in well-characterized populations for prostate and breast cancer, [more...]
Date: 2010-07-29 16:25:00
Colorado: Hispano DNA study results released
Tracing the Tribe is a blog about Jewish genealogy - All the developments, tools and resources you'll need to peer more closely into your family tree. Created in 2006 at JTA's request, it is now independent. Tracing the Tribe readers may remember several posts concerning a cluster of "Ashkenazi" breast cancer among Hispanic women in Colorado's San Luis Valley a few years ago. Later genealogical research showed the women were descendants of conversos (Jews forced to convert to Christianity during the Inquisition) who had settled in the area centuries ago. A paper in the San Luis area just [more...]
Date: 2010-08-25 14:00:00
Herbal News Magazine | Walgreens Plans to Sell a DNA Test Shelved
Walgreens, one of the fastest growing, and my personally favorite drugstore chain, has decided to put plans on hold for selling a new DNA saliva swab kit that they were planning to sell in their stores, probably bringing them to the forefront as the only drugstore chain to sell such a unique product. Why would people want a test like this, you ask? Well, DNA testing is becoming more and more popular as a way to detect whether you have damaged DNA and might be more likely to contract different diseases, or even be more prone to things like breast cancer and other inherited types of disease. I [more...]
Date: 2010-05-29 10:24:00
Progenika Receives CE Mark for First DNA Chip to Detect Mutations ...
The Leading Information Source for Chronic Disease Research and Management Metabolic Type I Diabetes Type II Diabetes Neuropathy Retinopathy Thyroid Disorder Addisons Disease Dialysis Kidney Disorders Obesity Cardiovascular Hypertension Cardiac Arrythmias Coronary Artery Disease Heart failure Angina Central Nervous System Parkinson's Disease Schizophrenia ADHD Anxiety Depression Epilepsy Obsessive Compulsive Disorder Alzheimer Dementia Fibromyalgia Lou Gehrig's Respiratory Asthma Bronchiectasis Cystic Fibrosis Chronic Obstructive Airways [more...]
Date: 2010-09-27 08:54:00
Distinctions Between Obesity and Waist-Hip Ratio
deCODE employs its capabilities to develop DNA-based tests and personal genome scans to better understand individual risk and empower prevention. It licenses its tests, intellectual property and analytical tools to partners, and conducts genotyping, sequencing and data analysis for companies and research institutions around the globe. Through its CLIA- and CAP-certified laboratory deCODE offers DNA-based tests for gauging risk and empowering prevention of common diseases, including deCODE Glaucoma(TM); deCODE T2(TM) for type 2 diabetes; deCODE AF(TM) for atrial fibrillation and stroke; deCODE [more...]
Date: 2010-10-11 18:15:07