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Regulating nutrigenetic tests: an international comparative ...

Regulating nutrigenetic tests: an international comparative analysis. Introduction In September 2007, the decoded genome of J. Craig Venter The introduction of this article is too short. To comply with Wikipedia's lead section guidelines, it should be expanded. , a pioneering genetics researcher, was released to the world. (1) This achievement attracted worldwide media attention, with stories making the inevitable leap from the publication of one man's genome to the promise of personalized medicine The external links in this article or section may require cleanup to comply with [more...]

Date: 2008-06-22 07:00:00

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The Lancet Student » Archive » Lancet Seminar: Porphyrias

Regularly updated lists of mutations are available from the Human Gene Mutation Database. Enzyme measurements are reserved for families in which a mutation cannot be identified (table 1). However, measurement of protoporphyrinogen, coproporphyringen oxidases, and even the widely used porphobilinogen-deaminase assay should be undertaken in a porphyria reference centre.27, 28 Pathogenesis and treatment All clinical features of an acute attack can be explained by lesions of the nervous system. The leading hypothesis is that 5-aminolaevulinic acid or other metabolites that are overproduced by the [more...]

Date: 2010-03-19 09:12:35


Retrovirology | Full text | Evolution of DC-SIGN use revealed by ...

© 2008 Borggren et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. AbstractBackground At early stages of infection CCR5 is the predominant HIV-1 coreceptor, but in approximately 50% of those infected CXCR4-using viruses emerge with disease progression. This coreceptor switch is correlated with an accelerated progression. However, those [more...]

Date: 2008-03-27 07:00:00


Agency Theory - What is Agency Theory - Agency Theory in Business ...

And one of the most prominent cases where there is a marked difference of opinion and different sets of priorities is the Agency Theory. Agency Theory is about differences in priorities between the principal who assigns the responsibility and that of his agent, who undertakes to discharge the principal’s responsibilities. Agency Theory involves dealing with the conflicts that arise between the two groups and the costs involved in resolving the conflicts. Agency Theory in Organizations: Agency Theory applies in an organisational perspective, in the form of differences between the owner of [more...]

Date: 2009-11-05 09:21:04


World Journal of Surgical Oncology | Full text | Male breast ...

The online cancer incidence database – Cancer Mondial (International Agency for Research on Cancer, Lyon, France) was also searched to provide incidence trends of male breast cancer from 1960–2000. Literature was meticulously reviewed and collated to obtain evidence about various aspects of the disease reviewed under the following sections. Epidemiology Though MBC is rare, a geographic variation in its incidence has been reported. It is higher in USA and UK than in Finland and Japan . National Cancer Institute data on cancer survival in the US shows increase in the incidence of MBC [more...]

Date: 2008-06-16 07:00:00


Molecular Cancer | Full text | Elevated level of anterior gradient ...

Previous studies have been conducted to investigate telomerase, microRNA, methylation, DNA mutation, and aberrant proteins as potential biomarkers in pancreatic juice from patients with pancreatic cancer or IPMNs (intraductal papillary mucinous neoplasms) . However, to our knowledge, there has not been any study to evaluate pancreatic juice samples from patients with PanIN3 lesions. In this study, we first applied mass spectrometry based quantitative proteomics to globally profile pancreatic juice samples from patients with histologically confirmed PanIN3 (referred as PanIN3 juice) to [more...]

Date: 2009-11-19 08:00:00


Critical Care | Full text | Changes in the central component of ...

Plasma concentrations of TSH were measured by a specific radioimmunoassay (RIA; reagents provided by Dr. A. Parlow, National Pituitary Agency). The detection limit was 1.2 mIU/l, and the intra assay coefficient of variation (CV) was 5.3%. In one sample from a prolonged ill rabbit TSH was below the detection limit. Total concentrations of plasma T4 and T3 were determined by an in-house RIA . The detection limit and intra assay CV were, 5 and 2 fmol and 2.8% and 2.2%, respectively. No free hormone determinations were performed because blood sampling was performed with heparinized catheters [more...]

Date: 2009-09-11 00:00:00


Virology Journal | Full text | Phylogenetic analyses of the ...

This complex intra-serotypic variation coupled with the presence of multiple serotypes has complicated disease control, which is achieved mainly by vaccination and restrictions on animal/animal product movement. In East Africa, most molecular studies have sought to identify phylogenetic relationships among viruses relying on the sequence of the VP1 coding region . Although used extensively for phylogenetic studies, the VP1 sequence alone may be inadequate for revealing all processes shaping diversity and evolution of the viruses in the region . Figure 1. Genomic structure of FMDV. [more...]

Date: 2010-09-14 04:52:30


Virology Journal | Full text | Evidence of structural genomic ...

Nevertheless, this mechanism can not be denied as a source for generating genetic diversity in natural populations of HCV, since a new intra-typic recombinant strain was found. Moreover, the recombination break-points were found in the structural region of the HCV genome.BackgroundHepatitis C virus (HCV) is estimated to infect 170 million people worldwide and creates a huge disease burden from chronic, progressive liver disease . HCV has become a major cause of liver cancer and one of the commonest indications of liver transplantation . HCV has been classified in the family [more...]

Date: 2006-08-05 07:00:00


Retrovirology | Full text | Characterization of the invariable ...

During HIV-1 assembly and maturation, the transformation of the virus from a spherical to a conical core structure results as a consequence of substantial inter- and intra-molecular rearrangements of one of the Pr55Gag derived proteins, namely the capsid protein (CAp24). This process is initially driven by the viral protease which sequentially cleaves Pr55Gag and liberates the mature structural proteins that forms the viral core structure . The mature conical HIV-1 core, which is composed of approximately 1500 CAp24 molecules , is comprised of two independently folded subunits, the N- [more...]

Date: 2007-09-26 07:00:00


Virology Journal | Full text | Evidence of recombination in ...

Phylogenetic analyses of HCV strains circulating in Peru, demonstrated the existence of natural intra-genotypic HCV recombinant strains (1a/1b) circulating in the Peruvian population . In these cases, the recombination events have taken place in the non-structural region of the HCV genome. Recombination break-points in HCV structural capsid genomic region has been recently identified . Given the implications that recombination has for RNA virus evolution , it is clearly important to determine the extent to which recombination plays a role in the evolution of HCV quasispecies [more...]

Date: 2006-11-08 08:00:00


Genome Biology | Full text | Optimization and clinical validation ...

Novel features of this platform include the development of a robust algorithm that accurately predicts PCR bias during DNA amplification and can be used to improve PCR primer design, as well as a powerful statistical concept for inferring .... This probability is reduced when intra-primer hairpin formation is predicted, and increased according to degree of complementarity between tag sequence and viral sequence. In this manner, the probability that each nucleotide will be [more...]

Date: 2007-05-27 00:00:00


A comparative genomic analysis of calcium and proton signaling ...

Unlike other secondary messengers, both calcium (Ca2+) and intra- cellular pH are not dependent on synthesis but rather on efficient regulation of calcium and proton concentration. In filamentous fungi, there is evidence for the involvement of ...... D192–D196 (database issue). Melin, P., Schnürer, J., Wagner, E.G., 2004. Disruption of the gene encoding the V-. ATPase subunit A results in inhibition of normal growth and abolished sporulation in Aspergillus nidulans. [more...]

Date: 2010-06-12 16:35:40


SAB PAH Mixtures Draft Report 09-08-10

The SAB convened the PAH. 41 Mixtures Review Panel, which held a public meeting from June 21-23, 2010 to provide advice to. 42 the Agency. The key points and recommendations of the Panel are detailed in the report. Below ..... 16 another PAH is advantageous since downstream calculations are intra-study and avoid. 17 comparisons without accounting for study effects/characteristics. It should be noted that the. 18 estimates of the BaP slope across studies are very different [more...]

Date: 2010-09-22 22:36:05


Sperm Specific Lysozyme-like Proteins invention

The novel intra-acrosomal c lysozyme-like protein hSLLP1 possesses 17 out of the 20 invariant residues of the c lysozymes including the all 8 cysteines but lacked both catalytic residues. ... 1990), a mouse orthologue of the human SLLP1 was sought in the NCBI GenBank database and a candidate gene identified. Single gene-specific forward (5'CAT GCC ATG GCC AAG GTC TTC AGT CGC TGT GAG CTG; SEQ ID NO: 14) and reverse primers (5'CCG CTC GAG GAA GTC ACA GCC ATC CAC CCA GTC; [more...]

Date: 2006-05-01 19:17:36



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